[3.22 Ancestor] Pneumatic MoltenStrike Trickster [50M+ DPS] | 30 DIVS to 40 DIVS.

Melee hit of 5.14m + 28.6 projectiles of 2.56m = 78M dps

Melee hit of 7.06m + 28.6 projectiles of 3.52m = 107M dps

4 from skill gem.
2 from helmet enchant.
1 from large cluster - fan of blades
1 from passive - Multishot
4 from gmp skill gem
1 from tattoo (Cost : 8 div) - least priority to get.
(Total 13 projectiles)

Double the number with Returning Projectile Support.
(Total 26 projectiles)

(Anomalous Returning Projectile has 20% chance to proc again).
(0.2 * 13 = 2.6 projectiles will proc again)

Hence, a total of 28.6 projectiles will spawn per cast.
Penalty from GMP and RP supports doesn't affect poison damage.

(1) Escape Artist - Go for ES helm, and ES mastery (+100% ES on equipped helm). Together with a good EV/ES body armour to increase defences.
(2) Soul Drinker - A little survivability, with nice attack speed
(3) Swift Killer - Extend charges duration. Enable us to have max charges (3/5/4).
(4) Polymath - nice extra damage.

Assassin's Toxic Delivery (Cost : About 40c each)
Poison you inflict with Critical Strikes deals 25% more Damage
+0.5% to Critical Strike Chance per Poison affecting Enemy, up to +2.0%

Needless to say, craft at two elemental lines, with T2 and above. Critical mods / Attack speed mods are good to have. Any other bonuses is fine too.
Must have an open prefix slot to craft : Hits can't be evaded

To be able to go low life = more auras = can wear better body armours > shavs.

Yup, Traitor will help us maintain our flasks longer. Able to keep uptime of flasks (without killing monsters) for about 2 minutes.
Flasks Gain 4 Charges per empty Flask Slot every 5 seconds

Look out for "% increased Flask Charges gained"
The rest are small bonuses.

ES gained on hit is essential due to the number of hits we deal. It's a huge layer of defence, and allows us to forgo Ghost Reaver.

(1) Double-corrupted gloves, with curse temporal chains + despair on hit.
(2) A corrupted glove with temporal chains on hit + rare ring with despair on hit (more expensive)

Well, any gloves work as long as there's these two corrupted implicits. But of course, choose the one which benefits the most according to your budget.

Of course this gloves give quite a bit of damage too.

A cheap way to unlock max curses limit. With one power charge in Shadow's area, we can have up to 4 curses easily without much investment.

(1) Temporal Chains (Curse on hit on gloves)
= allow your poison to last significantly longer = more dps.
(2) Despair (Curse on hit on gloves + Self-cast)
= reduce chaos resistance = more poison dmg.
(3) Assassin's Mark (Link with Mark on Hit)
= increases crit chance/dmg, as well as providing frenzy+power charges (mark mastery + superior quality gem)
(4) Punishment (Self-cast)
= increases damage by a huge amount when monster is at low life.

Yes. Curse on hit gives us a very good QoL. But why self-cast? It's because of this jewel.

Cost 1 div.

We just have to self-cast it every 10 seconds, or whenever we see rare/unique bosses. It's a must-have QoL jewel, instead of relying on wither totems which will die fast and not reliable.

Usually only rare/unique bosses. When you can see their life bar is about to hit 50%, just use punishment and you don't have to attack it anymore. Nice to see the hp bar go down with punishment :) yes it affects the poison damage

These two unique flasks grant us the greatest dps.
Ruby and Sapphire Flasks grant us more resistances to cover up from our gears.
You may choose to go 'Taste of Hate' as it gives us more tankiness. I prefer having more dps with this magic flask.
You may even go Topaz if you lack lightning resistance instead.

To grant us greater synergy due to 1 less flask (Traitor), it will be good to wear a Micro-Distillery Belt to maximize this synergy.

(1) Energy Shield
(2) Flask Charges gained/effect/duration. (Avoid reduced charges)
(3) Any other dps mod.
(4) Some stats/resist if possible.

Discipline (Any quality) - Precision - Arrogance - Wrath

You want as high ES as possible, some resist. An open prefix for physical damage from hits taken as fire.

Grace - Anger - Herald of Agony - Enlighten

Cost : 1 div.

Yes, thanks to this amulet, Wrath has no reservation costs, hence able to fully benefit from arrogance support. (You can link it with empower/enhance too (but lack of sockets).
Wrath is the best choice for damage, as well as given ES%!

Good amount of EV (to give ES from ascendency), as well as some ES as well. Suppression + some resistances. If you have an open prefix, go for physical damage from hits taken as fire/lightning damage.

Use eldritch ember to "Gain Endurance Charges every x seconds".
12% elemental resistances + 12% physical reduction is too good to miss.
Fully utilize our ascendency - Swift Killer.

Phantasmal Molten Strike - Multistrike - Awakened Elemental Damage with Attacks - Awakened Unbound Ailments - Greater Multiple Projectiles - Anomalous Returning Projectiles

The penalty from the projectile gems doesn't affect poison build.
More hits bring far too much more goodness than other support gems.
(a) More ES gained on Hit.
(b) Wither stacks up faster.
(c) Frenzy + Power charges up faster.
(d) Assuming not all projectiles will hit the enemy, more projectiles will overlap each other.

You don't need to have alternate qualities for most gems for a start. Eventually, you'll get it.
To do reflect maps without a worry, Awakened Elemental Damage is important.
Cost : 3 div

Try to get EV/ES boots.
Fractured : Suppression.
Essence Craft : Avoid Elemental Ailments.
Get some ES and resists.
Any other mods is a bonus.

Assassin's Mark - Mark on Hit
Despair / Steelskin

Decent EV/ES, with suppression. Some resists and a bit of damage with leftover open slots.

Whirling Blades / Frostblink / Ancestral Protector

Blood Rage - Punishment - Enhance

Just cast punishment on rare/unique monsters when they hit 50% life :)

Flat Elemental Damage, with Elemental Damage with Attack skills. ES, Stats, Resists.

I find that the Watcher's Eye ES gained on Hit is sufficient. I rather have the ES recharge when I'm not attacking, than to not heal any ES.