Random crashes everywhere, restarting the game takes 10+ tries

as the title says, I hope this will help GGG to find solutions for certain PC settings

Windows 11 Pro 64bit
SSD 1TB WD SN850X M.2 PCIe 4.0 x4 NVME(L 7300MB/s ; S 6300MB/s)
Mainboard Gigabyte Z790 GAMING X
Processor Intel(R) Core(TM) with 8C+16c/32T/ 6.00GHz Turbotakt, 36MB Cache
RAM 32GB (2x16GB) DDR5 AMD/Intel 6000MHz Kingston Fury Beast
Systemtyp 64-Bit x64
Card RTX 4080 16GB

Graphics settings in the game:
Display 4080 RTX
Direct 12 or Vulkan makes no difference
Nvidia DLSS active or not makes no difference
Vsync active or not makes no difference