Weapon routinely forgets about reduced requirements passive nodes

I grabbed the Reduced Attribute Requirements passive nodes down near Polymathy in order to equip a weapon. The weapon routinely stops working until I reequip it or change my Strength. This happens most often during screen transitions or when I have the other weapon set selected. I also have Giant's Blood, so it could be a bad interaction with that.

Bug#: 708,644,568

It looks like it might be caused by having the Reduced Attribute Requirements nodes being weapon set specific. (I thought I had checked for that, but the respeccing UI button was apparently broken.)