Dual monitor, not working on main monitor - Mouse over issue

Hey all,

I just started using dual Monitors.
Samsung Oddeysy G6

Installed my monitors and everything works fine. Have monitor 1 normal and monitor 2 standing.
If I start the PoE2 the game doesn't know my mouse, the login button does not work, when i move the mouse all the way to the right then it selects it.

When I use monitor 2, the standing one, it works fine.

Also when I run in windowed mode on 2, then drag it to 1 it works fine to.
Just as soon as i go to full screen, or Windowed full screen no borders it looses where my mouse pointer it.

I look for solutions, changed monitors, changed the cables, physically changed monitors, nothing works.

P.S. on other games i do not have this issue, just on PoE2

Anyone any ideas?